Strategies for Engineered Negligible Senescence (SENS), the brainchild of British biomedical gerontologist Aubrey de Grey, represents the most audacious initiative directed at the elimination of ageing.
The SENS program rests on the fundamental recognition of aging as resulting from damage accumulation of a various types. The program categorizes these forms of damage under seven types – the Seven Deadly Things. These Seven Deadly Sins are identified as 1 death resistant cells, 2 cell lose without replacement, 3 genetic and epigenetic mutations, 4 mitochondrial DNA damage, 5 extracellular cross-linking 6 extracellular junk accumulation 7 intracellular junk accumulation.
Not only has the SENS program identified these Seven Deadly Things but it has tendered seven corresponding strategies for addressing these forms of damage and has – most importantly – implemented seven strands of research dedicated to the implementation of the stated strategies.
Project Gilgamesh shares the fundamental view of SENS that aging is primarily the result of damage accumulation. Project Gilgamesh also makes recourse to aging in the evolutionary context and is informed by programmed theories of aging. The distinguishing feature of Project Gilgamesh is its approach to aging elimination as heavily reliant on molecular repair nanotechnology and the Principle of Minimal Interference. Project Gilgamesh emphasizes that developments in protein design, drug delivery and intelligent biological systems (such as DNA computing) will open up the way for more sophisticated nanotechnology. It also stresses the importance of the development of cancer nanotechnology as a starting point for the development of generic molecular repair nanotechnology.